2006:MIREX2006:General disclaimer

Adrenergic bronchodilators are medicines that stimulate the nerves in many parts of the body, causing different effects. Because these medicines open up the bronchial tubes (air passages) of the lungs, they are used to treat the symptoms of asthma, bronchitis, emphysema, and other lung diseases. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

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Epinephrine injection (including the auto-injector but not the sterile suspension) is used in the emergency treatment of allergic reactions to insect stings, medicines, foods, or other substances. It relieves skin rash, hives, and itching; wheezing; and swelling of the lips, eyelids, tongue, and inside of the nose. These medicines may be also used for other conditions as determined by your doctor. Ephedrine capsules are available without a prescription. However, check with your doctor before taking ephedrine. All of the other adrenergic bronchodilators are available only with your doctor's prescription.

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In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For adrenergic bronchodilators taken by mouth or given by injection, the following should be considered: Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to albuterol, ephedrine, epinephrine, isoproterenol, metaproterenol, or terbutaline. Also, tell your doctor if you are allergic to any other substances, such as foods, preservatives, or dyes. Pregnancy - Some of these medicines can increase blood sugar, blood pressure, and heart rate in the mother, and may increase the heart rate and decrease blood sugar in the infant. Before taking any of these medicines, make sure your doctor knows if you are pregnant or may become pregnant.

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Some of these medicines also relax the muscles of the uterus and may delay labor. For albuterol: Albuterol has not been studied in pregnant women. Studies in animals have shown that albuterol causes birth defects when given in doses many times the usual human dose. For ephedrine: Ephedrine has not been studied in pregnant women or in animals. For epinephrine: Epinephrine has been shown to cause birth defects in humans. However, this medicine may be needed during allergic reactions that threaten the mother's life. For isoproterenol: Studies on birth defects with isoproterenol have not been done in humans. However, there is some evidence that it causes birth defects in animals.

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For metaproterenol: Metaproterenol has not been studied in pregnant women. However, studies in animals have shown that metaproterenol causes birth defects and death of the animal fetus when given in doses many times the usual human dose. For terbutaline: Terbutaline has not been shown to cause birth defects in humans using recommended doses or in animal studies when given in doses many times the usual human dose.